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Theresa Denise Gaines
tgaines3@gsu.edu
www.justifiedgaines.com
Work Address:  P.O. Box 3965 • Atlanta, GA, 30302 • 404.413.5656

 

Education

Georgia State University, Atlanta, Georgia
Doctor of Philosophy, Organic Chemistry, August 2012 – Expected: May 2017
GPA: 3.9/4.0

Georgia State University, Atlanta, Georgia
Master of Science, Organic Chemistry, August 2012 – December 2015
GPA: 3.9/4.0

University of Notre Dame, South Bend, Indiana
Bachelor of Science, Chemistry, August 2008 – May 2012
GPA: 3.2/4.0

 

Awards and Honors

Nov 2016            NOBCChE Advancing Science Travel Grant Recipient
Sept 2016           1st Place Graduate Poster Session – Emory University STEM Research and Career Symposium
Sept 2015           NOBCChE Advancing Science Travel Grant Recipient
Jan 2013              GAANN Fellowship Awardee
Aug 2008            Questbridge Scholar

 

Publications

Theresa Gaines, Davita Camp, Renren Bai, Zhongxing Liang, Yonghyoun Yoon, Hyunsuk Shim, Suazette Reid Mooring. Synthesis and evaluation of 2,5 and 2,6 pyridine-based CXCR4 inhibitors. Bioorganic Medicinal Chemistry. 2016. doi:10.1016/j.bmc.2016.08.018

Renren Bai, Zhongxing Liang, Yonghyoun Yoon, Shuangping Liu, Theresa Gaines, Yoonhyeun Oum, Qi Shi, Suazette Reid Mooring, Hyunsuk Shim. Symmetrical bis-tertiary amines as novel CXCR4 inhibitors. European Journal of Medicinal Chemistry. 2016. 118(8), pp. 340-350. doi:10.1016/j.ejmech.2016.04.040.

Suazette Reid Mooring, Theresa Gaines, Zhongxing Liang, Hyunsuk Shim. Synthesis of pyridine derivatives as potential antagonists of chemokine receptor type 4. Heterocyclic Communications. 2014. 20(3), pp. 149-153. doi:10.1515/hc-2014-0041

 

Selected Presentations

Theresa Gaines, Suazette Mooring, Zhongxing Liang, Hyunsuk Shim. Design and Synthesis of Potential Heterocyclic Aromatic Based CXCR4 Modulators. Oral Presentation. 43rd NOBCChE National Conference. Raleigh, North Carolina. November 11, 2016.

Theresa Gaines, Davita Camp, Renren Bai, Zhongxing Liang, Yonghyoun Yoon, Hyunsuk Shim, Suazette Reid Mooring. Design and Synthesis of Potential Pyridine-based CXCR4 Modulators. Poster Presentation. Emory University STEM Research and Career Symposium. Atlanta, Georgia. September 19, 2016.

Theresa Gaines, Davita Camp, Renren Bai, Zhongxing Liang, Yonghyoun Yoon, Hyunsuk Shim, Suazette Reid Mooring. Design and synthesis of potential heterocyclic based CXCR4 modulators. Oral Presentation. 252nd American Chemical Society National Meeting. Philadelphia, PA. August 22, 2016.

Theresa Gaines, Suazette Mooring, Zhongxing Liang, Hyunsuk Shim. Design and Synthesis of Potential CXCR4 Modulators. Oral Presentation. 42nd NOBCChE National Conference. Orlando, Florida. September 24, 2015.

Theresa Gaines, Suazette Mooring, Zhongxing Liang, Hyunsuk Shim. Synthesis of pyridine and thiophene derivatives as potential antagonists of the chemokine receptor type 4. Poster Presentation. 248th American Chemical Society National Meeting. San Francisco, CA. August 10, 2014.

Theresa Gaines, Suazette Mooring. Design and Synthesis of Potential CXCR4 Antagonists. Poster Presentation. 65th Southeastern Regional Meeting of the American Chemical Society. Atlanta, GA. November 12-16, 2013.

 

Research Experience

Suazette Reid Mooring Laboratory
Graduate Research Assistant
Georgia State University, Atlanta, GA, August 2012 – Present
- Design, synthesize, purify and characterize novel small molecule inhibitors of C-X-C chemokine receptor type 4
- Synthesize analogues by reductive amination, PCC oxidation, MnO2 oxidation, and hydride reduction procedures
- Purify analogues through flash chromatography, thin layer chromatography and recrystallization
- Characterize analogues through 1H and 13C NMR spectroscopy, high resolution mass spectroscopy, and melting point analysis
- Appropriately manage and organize chemical waste and chemical inventory
- Enforce lab cleanliness and safety protocol per EPA regulations
- Collaborate with other research laboratories at Georgia State University and Emory University
- Cultivate and grow macrophage cell cultures to test hit compounds
- Train and mentor undergraduates and new graduate students in laboratory techniques, conduct and safety

Marvin J Miller Laboratory
Undergraduate Researcher
University of Notre Dame, Notre Dame, IN, January 2010 – May 2011
- Synthesize, purify and characterize new small molecule antibiotic analogues for drug resistant Tuberculosis strains
- Synthesize compounds by EDC coupling reaction
- Purify compounds through flash chromatography and thin layer chromatography
- Characterize analogues through NMR Spectroscopy and melting point analysis
- Collaborated with and presented findings to graduate students and professors

 

Teaching Experience

Integrated Science Co-Instructor and Chemistry Liaison
Integrated Science III: Biology and Chemistry
Georgia State University, Atlanta, GA, August 2016 – Present
- Prepare College of Education students to teach K-8 Earth Science, Life Science and Physical Science per Georgia Performance Standards
- Create and demonstrate hands on activities for core concepts that these students may use in their classrooms
- Build a strong elementary foundation in chemistry, macromolecules and polymers so that students may better contextualize broader systems like DNA replication, photosynthesis or energy transfer in ecosystems.
- Equip students with resources and tools to design and create their own activities and experiments for their class
- Cultivate a deep understanding of the scientific method in students.
- Train students to critically evaluate scientific literature and discuss experimental methodology and conclusions 

Instructor of Record
Chemistry 1211 Laboratory
Georgia State University, Atlanta, GA, January 2016 – April 2016
- Prepare, proctor and grade homework assignments, exams, quizzes, lab reports and laboratory notebooks
- Address students’ questions and concerns
- Enforce laboratory safety
- Equip students with necessary skills and techniques to think critically to identify an unknown compound
- Guide students to connect abstract concepts from lecture to concrete problems in the laboratory setting

Bio-Bus GAANN Fellow
Georgia State University Bio-Bus Program
Georgia State University, Atlanta, GA, January 2013 – Present
- Engage and teach K-12 students various science lessons in an interactive and fun setting
- Spend 150 hours per fall and spring semester teaching K-12 students
- Teach K-12 students for 100 hours during the summer in libraries and summer camps
- Create, develop and implement novel teaching materials and modules to add to the Bio-Bus catalogue
- Prepare and organize teaching materials and activities for each lesson
- Mentor and guide new fellows in teaching the material through tutorials, feedback and collaborative teaching
- Teach high school students how to use a pipette and run a gel electrophoresis experiment
- Extract DNA from split peas with K-6th graders
- Create polymers with K-8th graders and explain their purpose and use

Teaching Assistant – Flipped Classroom
Organic Chemistry I
Georgia State University, Atlanta GA, August 2015 - December 2015
- Guide students to think critically as they work on organic chemistry problems in class
- Clarify and explain main concepts of organic chemistry to students using concepts previously mastered
- Encourage students to review material outside of class to promote learning retention
- Teach students how to use molecular model kits to visualize molecules in three-dimensional space
- Grade exams and quizzes 

Workshop Instructor
Bio-Bus 2015 Librarian’s Workshop and Bio-Bus 2015 SEPA Teacher’s Workshop
Georgia State University, Atlanta, GA, May 7, 2015 and June 1 – 5, 2015
- Teach K-12 instructors and local librarians about DNA through Bio-Bus’ DNA is Elementary curriculum
- Equip K-12 instructors and local librarians with resources and tools to teach their students about DNA
- Train K-12 instructors how to prepare and run a PCR experiment
- Teach K-12 instructors how to prepare and calculate quantities in solutions and dilutions
- Build confidence in K-12 instructors and local librarians to effectively teach science in their classroom to inspire and cultivate a desire to learn in their students. 

Teaching Assistant
Organic Chemistry I Lab
Georgia State University, Atlanta, GA, August 2012 – May 2013
- Guide students to problem solve using laboratory techniques and concepts to characterize and identify an unknown compound
- Address student questions and concerns
- Proctor and grade exams, reports, notebooks and quizzes
- Supervise students in development of lab techniques and principles
- Enforce laboratory safety protocol

Organic Chemistry Tutor
Learning Resource Center
University of Notre Dame, Notre Dame, IN, January 2011 – May 2012
- Lead sessions for thirty underclassmen to review organic chemistry topics covered in class
- Emphasize basic concepts of chemistry to improve student’s grades and confidence

 

Mentoring

-          Mentoring includes:

o   Teaching and training mentees about laboratory safety
o   Overseeing mentees in the laboratory
o   Promoting proper lab notebook upkeep and guidelines
o   Enabling mentees to translate prior laboratory experience to a research setting
o   Cultivating critical thinking skills in mentees as they work on their individual projects
o   Guiding mentees as they navigate through problems in their projects

Mentees:
Francisco Garcia—Master’s student (June 2013 – Present)
Imienreluefe Adodo—Undergraduate student, (June 2013 – December 2015)
Luna Soufi—Undergraduate student (January 2015- May 2015)
Tshibambe Nathanael Tshimbombu—Undergraduate student (June 2014 – July 2015)
Callie Stern—Undergraduate student (June 2015 – May 2016)
Saniya Viryani—Undergraduate student (August 2015 – July 2016), Master’s Student (August 2016 – Present)
Damilola Gbadebo—Undergraduate student (January 2016 – Present)   

 

Skills

Language(s):

-          Russian – Conversational Proficiency
-          German – Elementary Proficiency
-     Spanish – Elementary Proficiency

 

Software:

- Bruker Topspin (NMR Data Analysis and Processing)
- ACD Labs (NMR Data Analysis and Processing)
- ChemBioDraw (Graphing Chemical Structures)
- Spartan (Molecular Modeling)
- Hyperchem (Molecular Modeling)
- PC Model (Molecular Modeling)
- Pymol (Molecular Modeling)
- Microsoft Office
- EndNote

 

Instrumentation:

- One-dimensional and two-dimensional nuclear magnetic resonance experiments (Bruker)
- UV-Visible spectrometer
- Infrared spectrometer
- Gas chromatograph
- Rotary evaporator
- Vacuum pump and Schlenk apparatus

 

Laboratory Techniques:

-          Flash Chromatography
-          Thin Layer Chromatography
-     Preparatory Thin Layer Chromatography
-     Small molecule synthesis, purification and isolation
-     Gel Electrophoresis
-     Polymerase Chain Reaction
-     Cell cultivation and plating

 

Professional Affiliations:

Oct 2014 – Present         National Organization for the Professional Advancement for Black Chemists and Chemical Engineers (National Member)

May 2014 – Present       American Chemical Society (National Member)

Aug 2013 – Present       Georgia State University Graduate Student Association (Member)

May 2013 – Present       Association for Women in Science (Member)

Aug 2012 – Present     Chemistry Graduate Student Association (Member)